Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations

TitleHierarchies in eukaryotic genome organization: Insights from polymer theory and simulations
Publication TypeJournal Article
Year of Publication2011
AuthorsBVS Iyer, M Kenward, and G Arya
JournalBmc Biophysics
Volume4
Issue1
Start Page8
Pagination8 - 8
Date Published01/2011
Abstract

Eukaryotic genomes possess an elaborate and dynamic higher-order structure within the limiting confines of the cell nucleus. Knowledge of the physical principles and the molecular machinery that govern the 3D organization of this structure and its regulation are key to understanding the relationship between genome structure and function. Elegant microscopy and chromosome conformation capture techniques supported by analysis based on polymer models are important steps in this direction. Here, we review results from these efforts and provide some additional insights that elucidate the relationship between structure and function at different hierarchical levels of genome organization. © 2011 Iyer et al; licensee BioMed Central Ltd.

DOI10.1186/2046-1682-4-8
Short TitleBmc Biophysics