Postdoctoral Fellow
My current research is in the area of DNA nanotechnology, in particular on the computational modeling of higher-order assembly and collective dynamics of DNA tiles. I’m also interested in how to control DNA nanodevices through the use of external electric and magnetic fields, which can significantly modify the geometrical conformation of these devices with rapid actuation response times. During my PhD studies, I worked on the development of biosensors for early diagnosis of DNA-related diseases, focusing on the use of theoretical and computational models to better understand how different impedance-based biosensors work. Outside of research, I enjoy hiking, sightseeing, and listening to classic rock music.
Contact Information
- Office Location: 3353 CIEMAS
- Email Address: sebastian.sensale.rodriguez@duke.edu
Education
- Pure Mathematics, Universidad de la Republica, 2014
- PhD: Bioengineering, University of Notre Dame, 2020
Research Interests
My current research is in the area of DNA nanotechnology, in particular on the computational modeling of higher-order assembly and collective dynamics of DNA tiles. I’m also interested in how to control DNA nanodevices through the use of external electric and magnetic fields, which can significantly modify the geometrical conformation of these devices with rapid actuation response times. During my PhD studies, I worked on the development of biosensors for early diagnosis of DNA-related diseases, focusing on the use of theoretical and computational models to better understand how different impedance-based biosensors work.
Representative publications:
- Sensale, S; Wang, C; Chang, H-C., Resistive amplitude fingerprints during translocation of linear molecules through charged solid-state nanopores. J. Chem. Phys. 153, 035102 (2020) [doi: 10.1063/5.0013195]
- Sensale, S; Peng, Z; Chang, H-C., Biphasic signals during nanopore translocation of DNA and nanoparticles due to strong ion cloud deformation. Nanoscale 11, 22772-22779 (2019) [doi: 10.1039/C9NR05223B]
- Sensale, S; Peng, Z; Chang, H-C., Acceleration of DNA melting kinetics using alternating electric fields. J. Chem. Phys. 149, 085102 (2018) [doi: 10.1063/1.5039887]
- Sensale, S; Peng, Z; Chang, H-C., Kinetic theory for DNA melting with vibrational entropy. J. Chem. Phys. 147, 135101 (2017) [doi: 10.1063/1.4996174]