Biophysics of DNA Packaging

<p><span><span>Many double stranded DNA bacteriophages use powerful molecular motors to package their genome into their capsids. Thanks to high-resolution structures, single molecule experiments, and computational modelling, we are now beginning to understand the elaborate mechanisms governing these motors’ functions. Here we provide an overview of the biophysical characterization of these systems, primarily focusing on the φ29, T4, and λ bacteriophages. Biophysical properties such as packaging speed, force generation, mechanochemical coupling, and motor coordination are discussed.</span></p>