Biophysics of DNA Packaging

TitleBiophysics of DNA Packaging
Publication TypeBook Chapter
Year of Publication2021
AuthorsJ Pajak, G Arya, and DE Smith
Book TitleEncyclopedia of Virology (Fourth Edition)
ChapterBiophysics of DNA Packaging
Series Volume4
Pagination160 - 166
Other Numbers10.1016/B978-0-12-809633-8.20966-7

<p><span><span>Many double stranded DNA bacteriophages use powerful molecular motors to package their genome into their capsids. Thanks to high-resolution structures, single molecule experiments, and computational modelling, we are now beginning to understand the elaborate mechanisms governing these motors’ functions. Here we provide an overview of the biophysical characterization of these systems, primarily focusing on the φ29, T4, and λ bacteriophages. Biophysical properties such as packaging speed, force generation, mechanochemical coupling, and motor coordination are discussed.</span></p>