Title | Models for recovering the energy landscape of conformational transitions from single-molecule pulling experiments |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | G Arya |
Journal | Molecular Simulation |
Volume | 42 |
Start Page | 1102 |
Issue | 13 |
Pagination | 1102 - 1115 |
Date Published | 09/2016 |
Abstract | © 2016 Informa UK Limited, trading as Taylor & Francis Group. Single-molecule force spectroscopy is a powerful experimental technique for probing intermolecular forces and conformational transitions of individual molecules. This technique involves measuring the mechanical response of a molecule subjected to a constant or time-varying force. Statistical mechanics has played a pivotal role in interpreting force measurements in terms of the underlying kinetics and energy landscape of the molecular transition being studied. Here, we provide a didactic review of various statistical–mechanical models used for analysing these measurements, emphasising the theoretical ideas and assumptions used in deriving these models. |
DOI | 10.1080/08927022.2015.1123257 |
Short Title | Molecular Simulation |