Models for recovering the energy landscape of conformational transitions from single-molecule pulling experiments

TitleModels for recovering the energy landscape of conformational transitions from single-molecule pulling experiments
Publication TypeJournal Article
Year of Publication2016
AuthorsG Arya
JournalMolecular Simulation
Volume42
Issue13
Start Page1102
Pagination1102 - 1115
Date Published09/2016
Abstract

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Single-molecule force spectroscopy is a powerful experimental technique for probing intermolecular forces and conformational transitions of individual molecules. This technique involves measuring the mechanical response of a molecule subjected to a constant or time-varying force. Statistical mechanics has played a pivotal role in interpreting force measurements in terms of the underlying kinetics and energy landscape of the molecular transition being studied. Here, we provide a didactic review of various statistical–mechanical models used for analysing these measurements, emphasising the theoretical ideas and assumptions used in deriving these models.

DOI10.1080/08927022.2015.1123257
Short TitleMolecular Simulation