Nanofiber-Based Total Internal Reflection Microscopy for Characterizing Colloidal Systems at the Microscale

TitleNanofiber-Based Total Internal Reflection Microscopy for Characterizing Colloidal Systems at the Microscale
Publication TypeJournal Article
Year of Publication2018
AuthorsJT Villanueva, Q Huang, NO Fischer, G Arya, and DJ Sirbuly
JournalThe Journal of Physical Chemistry C
Volume122
Issue38
Start Page22114
Pagination22114 - 22124
Date Published01/2018
Abstract

© 2018 American Chemical Society. Bulk colloidal interactions are dictated by the physical properties of individual particles dispersed in solution. However, for many applications it remains challenging to predict system-level colloidal behavior. Comprehensive characterization typically requires disparate techniques that can observe correlations between microscale particle-surface interactions and physical properties of the particles. In this work, we present a unique tin dioxide (SnO2) nanofiber-based total internal reflection microscopy (TIRM) method to efficiently characterize colloidal behavior as a function of particle-level properties in complex fluidic conditions. We develop and model the device physics to understand the physical underpinnings of the raw device data and then use these models to design proof-of-concept experiments to verify device function. Statistical trends in the data collected from a nominal system of 80 nm gold nanoparticles correspond to theoretical predictions as we vary key design parameters such as particle size, surface charge, and solution ionic strength. Lastly, we consider the practical limitations of the technique gleaned from our studies and offer suggestions for utilizing the platform to quantitatively analyze nonideal colloidal systems with distributed or heterogeneous system parameters.

DOI10.1021/acs.jpcc.8b03167
Short TitleThe Journal of Physical Chemistry C