Title | A structural perspective on the where, how, why, and what of nucleosome positioning. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | G Arya, A Maitra, and SA Grigoryev |
Journal | Journal of Biomolecular Structure & Dynamics |
Volume | 27 |
Issue | 6 |
Start Page | 803 |
Pagination | 803 - 820 |
Date Published | 06/2010 |
Abstract | The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped around a histone octamer, and a stretch of relatively unconstrained DNA called the linker DNA. Since nucleosome cores occlude the DNA from many DNA-binding factors, their positions provide important clues for understanding chromatin packing and gene regulation. Here we review the recent advances in the genome-wide mapping of nucleosome positions, the molecular and structural determinants of nucleosome positioning, and the importance of nucleosome positioning in chromatin higher order folding and transcriptional regulation. |
DOI | 10.1080/07391102.2010.10508585 |
Short Title | Journal of Biomolecular Structure & Dynamics |